Whole‐brain atrophy as a measure of progression in premanifest and early Huntington's disease
Identifieur interne : 001F82 ( Main/Exploration ); précédent : 001F81; suivant : 001F83Whole‐brain atrophy as a measure of progression in premanifest and early Huntington's disease
Auteurs : Susie M. D. Henley [Royaume-Uni] ; Edward J. Wild [Royaume-Uni] ; Nicola Z. Hobbs [Royaume-Uni] ; Chris Frost [Royaume-Uni] ; David G. Macmanus [Royaume-Uni] ; Roger A. Barker [Royaume-Uni] ; Nick C. Fox [Royaume-Uni] ; Sarah J. Tabrizi [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Atrophy, Atrophy (etiology), Atrophy (pathology), Brain (pathology), Brain Mapping, CAG repeat length, Disease Progression, Encephalon, Humans, Huntington Disease (complications), Huntington Disease (pathology), Huntington disease, Huntington's disease, MRI, Magnetic Resonance Imaging (methods), Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Severity of Illness Index, longitudinal.
- MESH :
- complications : Huntington Disease.
- etiology : Atrophy.
- methods : Magnetic Resonance Imaging.
- pathology : Atrophy, Brain, Huntington Disease.
- Adult, Brain Mapping, Disease Progression, Humans, Middle Aged, Severity of Illness Index.
Abstract
Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole‐brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole‐brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI‐based measures of whole‐brain atrophy may have potential as a measure of progression in HD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22485
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001631
- to stream Istex, to step Curation: 001631
- to stream Istex, to step Checkpoint: 000B84
- to stream PubMed, to step Corpus: 001D94
- to stream PubMed, to step Curation: 001D94
- to stream PubMed, to step Checkpoint: 001A95
- to stream Ncbi, to step Merge: 002583
- to stream Ncbi, to step Curation: 002583
- to stream Ncbi, to step Checkpoint: 002583
- to stream Main, to step Merge: 002843
- to stream PascalFrancis, to step Corpus: 000E86
- to stream PascalFrancis, to step Curation: 001E33
- to stream PascalFrancis, to step Checkpoint: 000C54
- to stream Main, to step Merge: 002D51
- to stream Main, to step Curation: 001F82
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Whole‐brain atrophy as a measure of progression in premanifest and early Huntington's disease</title><author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name></author><author><name sortKey="Wild, Edward J" sort="Wild, Edward J" uniqKey="Wild E" first="Edward J." last="Wild">Edward J. Wild</name></author><author><name sortKey="Hobbs, Nicola Z" sort="Hobbs, Nicola Z" uniqKey="Hobbs N" first="Nicola Z." last="Hobbs">Nicola Z. Hobbs</name></author><author><name sortKey="Frost, Chris" sort="Frost, Chris" uniqKey="Frost C" first="Chris" last="Frost">Chris Frost</name></author><author><name sortKey="Macmanus, David G" sort="Macmanus, David G" uniqKey="Macmanus D" first="David G." last="Macmanus">David G. Macmanus</name></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name></author><author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3E9A7A64E93EA9F6630A1259612290A193603493</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22485</idno><idno type="url">https://api.istex.fr/document/3E9A7A64E93EA9F6630A1259612290A193603493/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001631</idno><idno type="wicri:Area/Istex/Curation">001631</idno><idno type="wicri:Area/Istex/Checkpoint">000B84</idno><idno type="wicri:doubleKey">0885-3185:2009:Henley S:whole:brain:atrophy</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19243073</idno><idno type="wicri:Area/PubMed/Corpus">001D94</idno><idno type="wicri:Area/PubMed/Curation">001D94</idno><idno type="wicri:Area/PubMed/Checkpoint">001A95</idno><idno type="wicri:Area/Ncbi/Merge">002583</idno><idno type="wicri:Area/Ncbi/Curation">002583</idno><idno type="wicri:Area/Ncbi/Checkpoint">002583</idno><idno type="wicri:Area/Main/Merge">002843</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:09-0223230</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E86</idno><idno type="wicri:Area/PascalFrancis/Curation">001E33</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000C54</idno><idno type="wicri:doubleKey">0885-3185:2009:Henley S:whole:brain:atrophy</idno><idno type="wicri:Area/Main/Merge">002D51</idno><idno type="wicri:Area/Main/Curation">001F82</idno><idno type="wicri:Area/Main/Exploration">001F82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Whole‐brain atrophy as a measure of progression in premanifest and early Huntington's disease</title><author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wild, Edward J" sort="Wild, Edward J" uniqKey="Wild E" first="Edward J." last="Wild">Edward J. Wild</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hobbs, Nicola Z" sort="Hobbs, Nicola Z" uniqKey="Hobbs N" first="Nicola Z." last="Hobbs">Nicola Z. Hobbs</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Frost, Chris" sort="Frost, Chris" uniqKey="Frost C" first="Chris" last="Frost">Chris Frost</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Macmanus, David G" sort="Macmanus, David G" uniqKey="Macmanus D" first="David G." last="Macmanus">David G. Macmanus</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NMR Research Unit, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Brain Repair Centre, Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Institute of Neurology, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-30">2009-04-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="932">932</biblScope><biblScope unit="page" to="936">936</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3E9A7A64E93EA9F6630A1259612290A193603493</idno><idno type="DOI">10.1002/mds.22485</idno><idno type="ArticleID">MDS22485</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Atrophy</term><term>Atrophy (etiology)</term><term>Atrophy (pathology)</term><term>Brain (pathology)</term><term>Brain Mapping</term><term>CAG repeat length</term><term>Disease Progression</term><term>Encephalon</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (pathology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>MRI</term><term>Magnetic Resonance Imaging (methods)</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Severity of Illness Index</term><term>longitudinal</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atrophy</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term><term>Brain</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Disease Progression</term><term>Humans</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie</term><term>Chorée de Huntington</term><term>Encéphale</term><term>Imagerie RMN</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole‐brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole‐brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI‐based measures of whole‐brain atrophy may have potential as a measure of progression in HD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name></region><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><name sortKey="Frost, Chris" sort="Frost, Chris" uniqKey="Frost C" first="Chris" last="Frost">Chris Frost</name><name sortKey="Frost, Chris" sort="Frost, Chris" uniqKey="Frost C" first="Chris" last="Frost">Chris Frost</name><name sortKey="Hobbs, Nicola Z" sort="Hobbs, Nicola Z" uniqKey="Hobbs N" first="Nicola Z." last="Hobbs">Nicola Z. Hobbs</name><name sortKey="Macmanus, David G" sort="Macmanus, David G" uniqKey="Macmanus D" first="David G." last="Macmanus">David G. Macmanus</name><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name><name sortKey="Wild, Edward J" sort="Wild, Edward J" uniqKey="Wild E" first="Edward J." last="Wild">Edward J. Wild</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:3E9A7A64E93EA9F6630A1259612290A193603493
|texte= Whole‐brain atrophy as a measure of progression in premanifest and early Huntington's disease
}}
| This area was generated with Dilib version V0.6.23. |  |